OrthoSera Kft received the TOP10 most interesting hungarian innovation 2018-2019 prize for the BoneAlbumin product

BoneAlbumin is a
human allograft.

The bone substitute may be:
– mineral based, synthetic,
– xenograft from a species other than human,
– allograft made from allogenic human tissue,
– or autograft removed from other body parts of the patient.
The latter, which is certainly the best solution, should be avoided, since the surgical risk is doubled and it is an unnecessary exertion in case of a good allograft.

BoneAlbumin is an allograft processed from human tissue.

How does it work?


Mixing BoneAlbumin with a drop of blood results in an easily formable paste, which can be implanted into the bone cavity with a Volkmann spoon. It can be compressed or mixed with autogenous bone, if necessary.


The morphology and components of human bone form an ideal frame, while the local high albumin concentration supports the growth of stem cells and therefore the growth of the new tissue, as well.


The crystalline frame of BoneAlbumin fills the whole cavity during its slow degradation until the slowly formed bone tissue takes its place.


A strong and load-bearing bone providing an ideal support for the implants is the result of the complete integration and restructuring of the graft.

Scientific results


demonstrated that bone marrow stem cells adhere and proliferate on the surface of BoneAlbumin while cells were hardly detected on the surface of bovine bone or ceramics.


albumin coating accelerated graft integration and, more importantly, resulted in high- density bone with increased fracture resistance.


BoneAlbumin has been used for filling large bone defects since 2010. Multiple authorized studies have demonstrated its safety and efficacy.


human oral surgeon studies evinced that BoneAlbumin results better integration into the human body comparing to BioOss when they were used for socket preservation.

Who are we?

OrthoSera is a regenerative medicine company harnessing the power of blood serum for human diseases. Our R&D is currently focused on bone grafting, osteoarthritis, wound healing, as well as dental and orthopedic indications. Blood serum has a high regenerative potential and based on this fact OrthoSera has already developed two technologies.

BoneAlbumin is essentially a serum albumin enhanced bone allograft that was shown to activate bone marrow stem cells leading to faster and better bone healing. This tissue product is already in commercial stage with two double-blind clinical studies proving its effectiveness in sports surgery and dentistry. Our next technology takes this concept even further, as we use a proprietary method to isolate a specific, growth-factor rich serum fraction (hyperacute serum or hypACTTM) that has shown superior effects in promoting cell proliferation in osteoarthritic bone, cartilage, and mesenchymal stem cells among others.

Hyperacute serum is also patent-covered and can be applied at the bedside with our CE-marked medical device, hypACT inject.

Learn About Our Leading Technologies

OrthoSera received an innovation prize

OrthoSera received an innovation prize

OrthoSera Kft received the TOP10 most interesting hungarian innovation 2018-2019 prize for the BoneAlbumin product!

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Orthosera Dental at the Europerio9 conference

Orthosera Dental at the Europerio9 conference

The forthcoming conference of OrthoSera Dental: EuroPerio9 – June 20-23 2018, Amsterdam OrthoSera Dental is also participating in the EuroPerio9 Conference, which is...

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Perspectives in Perio-Implantology and Comprehensive Dentistry

Perspectives in Perio-Implantology and Comprehensive Dentistry

University of Szeged, Study and Information Centre 11-12 May 2018, Szeged As every year, the traditional Spring Dental Conference was organized in Szeged in May...

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Perfect solution

The human bone substitute is recognized as “more identical”, and the human body gives it a warmer welcome than the products from another species..

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